Thrombus - 2008


The pathogenesis of Lemierre’s syndrome
Samreen Siddiq, Owen Williams and Andrew Mumford
pp 1-3
Thrombosis of the internal jugular vein (IJV) is an uncommon condition that is usually associated with direct trauma from indwelling venous catheters, or through intravenous drug abuse. Less commonly, IJV thrombosis may be precipitated by localised sepsis in oropharyngeal tissues adjacent to the IJV.
Comment: Oral anticoagulation for atrial fibrillation
Peter Rose
pp 2-2
The benefit in symptomatic atrial fibrillation (AF) of oral anticoagulant therapy is well established in clinical trials. Overall, stroke is five to six times more prevalent in patients with AF, with a 1% risk per year for patients over 65 years with no risk factors, rising to 12% per year for patients over 65 years with previous stroke, transient ischaemic attack (TIA) or venous thromboembolic disease.
Multidisciplinary management of VTE
Peter Rose and Grace O’Hare
pp 4-5
The modern day management of venous thromboembolism (VTE) is best undertaken using a multidisciplinary approach. This involves a formal assessment with core members providing the clinical, diagnostic and treatment input to the management plan. It is important that the diagnosis is confirmed, as radiological investigations can often be misinterpreted. Each patient requires a risk assessment for recurrence of VTE and bleeding risk.
Disseminated intravascular coagulation
Louise Knowlson and Katie Randall
pp 6-8
Disseminated intravascular coagulation (DIC) is a complicated, life-threatening condition that is usually coupled with an equally serious underlying cause. In this article, the diagnosis of patients with DIC and practical issues in the management of this diverse group are discussed.
Why use computerised decision support software?
David Fitzmaurice
pp 10-10
Oral anticoagulation management is a complicated business because of the nature of oral anticoagulants. Not only do they have a very narrow therapeutic window, they are also affected by numerous drugs, foods, alternative medications and, of course, alcohol.

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